The above information is offered for common informational and educational purposes only. Unique programs could range and formulary information modifications. Get hold of the relevant strategy supplier for the most recent information.
topiramate will lessen the level or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
lapatinib will boost the degree or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
As can transpire with any medicine, a couple of people today may perhaps develop an allergic response. When you expertise any of the subsequent, convey to your doctor instantly:
Suicidal views or actions is often due to items in addition to medicines. For those who have suicidal feelings or steps, your Health care supplier may perhaps look for other causes.
Monitor Carefully (one)larotrectinib will increase the degree or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Powerful or reasonable CYP3A4 inhibitors may possibly lessen level of diazepam elimination, thus expanding adverse reactions to diazepam.
Monitor Closely (one)crofelemer increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Crofelemer has the likely to inhibit CYP3A4 at concentrations anticipated within the intestine; not likely to inhibit systemically since minimally absorbed.
N-desmethyldiazepam and temazepam are the two even further metabolized to oxazepam. Temazepam and check here oxazepam are mainly eliminated by glucuronidation.
diazepam will enhance the stage or influence of flibanserin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Amplified flibanserin adverse outcomes may possibly take place if coadministered with several weak CYP3A4 inhibitors.
For patients working with taken care of a lot more often than recommended, to lower possibility of withdrawal reactions, use a gradual taper to discontinue therapy (a patient-specific system must be used to taper the dose)
nevirapine will minimize the extent or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
efavirenz will minimize the extent or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Lencapavir (a average CYP3A4 inhibitor) might boost CYP3A4 substrates initiated within just nine months just after last SC dose of lenacapavir, which may improve likely possibility of adverse reactions of CYP3A4 substrates.
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